Ciclopoli

Ciclopoli may be available in the countries listed below.

Ingredient matches for Ciclopoli

Ciclopirox

Ciclopirox is reported as an ingredient of Ciclopoli in the following countries:

• Germany


• Switzerland

Ciclopirox olamine (a derivative of Ciclopirox) is reported as an ingredient of Ciclopoli in the following countries:

• Germany

International Drug Name Search

Risperidone

Pronunciation: ris-PER-i-done
Generic Name: Risperidone
Brand Name: Risperdal Consta

Risperidone is an antipsychotic. It may increase the risk of death when used to treat mental problems caused by dementia in elderly patients. Most of the deaths were linked to heart problems or infection. Risperidone is not approved to treat mental problems caused by dementia.

Risperidone is used for:

Treating schizophrenia. It may be used alone or with other medicine to treat bipolar disorder. It may also be used for other conditions as determined by your doctor.

Risperidone is an atypical antipsychotic. It works by affecting certain substances in the brain.

Do NOT use Risperidone if:

• you are allergic to any ingredient in Risperidone

Contact your doctor or health care provider right away if this applies to you.

Before using Risperidone:

Some medical conditions may interact with Risperidone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of seizures, heart problems (eg, heart failure, slow or irregular heartbeat), abnormal electrocardiogram (ECG), heart attack, stroke, blood vessel problems, high or low blood pressure, high cholesterol or triglyceride levels, or low white blood cell levels


• if you have a history of kidney or liver problems, stomach or bowel problems (eg, narrowing, blockage), neuroleptic malignant syndrome (NMS), suicidal thoughts or attempts, or alcohol abuse or dependence


• if you have diabetes or are very overweight, or if a family member has had diabetes


• if you have Alzheimer disease, dementia, Parkinson disease, or esophagus problems (eg, trouble swallowing)


• if you have had high blood prolactin levels or a history of certain types of cancer (eg, breast, pancreas, pituitary, brain), or if you are at risk for breast cancer


• if you are dehydrated, drink alcohol, or will be exposed to very high or very low temperatures

Some MEDICINES MAY INTERACT with Risperidone. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Alpha-blockers (eg, doxazosin) or medicine for high blood pressure because the risk of low blood pressure and fainting may be increased


• Anticholinergics (eg, scopolamine) because the risk of overheating may be increased


• Tramadol because the risk of seizures may be increased


• Clozapine or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine, paroxetine) because they may increase the risk of Risperidone's side effects


• Carbamazepine, phenobarbital, phenytoin, or rifampin because they may decrease Risperidone's effectiveness


• Dopamine receptor agonists (eg, pramipexole) or levodopa because their effectiveness may be decreased by Risperidone

This may not be a complete list of all interactions that may occur. Ask your health care provider if Risperidone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Risperidone:

Use Risperidone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Risperidone is usually given as an injection at your doctor's office, hospital, or clinic. Be sure to keep all doctor appointments while using Risperidone.


• Do not use Risperidone if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.


• Continue to use Risperidone even if you feel well. Do not miss any doses.


• If you miss a dose of Risperidone, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Risperidone.

Important safety information:

• Risperidone may cause drowsiness, dizziness, light-headedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Risperidone with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol while you are using Risperidone.


• Check with your doctor before taking medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Risperidone; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Risperidone may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Do not become overheated in hot weather or while you are being active; heatstroke may occur.


• Patients who have bipolar (manic-depressive) illness, or if their family members have had it, may be at increased risk for suicidal thoughts or actions. Watch patients who take Risperidone closely. Contact the doctor at once if new, worsened, or sudden symptoms such as anxious, restless, or irritable behavior; depressed mood; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.


• Risperidone may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.


• Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Risperidone may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.


• Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Risperidone. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.


• Some patients who take Risperidone may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Risperidone in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Risperidone.


• Risperidone may increase the amount of a certain hormone (prolactin) in your blood. Symptoms may include enlarged breasts, missed menstrual period, decreased sexual ability, or nipple discharge. Contact your doctor right away if you experience any of these symptoms.


• Risperidone may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.


• Lab tests, including fasting blood glucose and complete blood cell counts, may be performed while you use Risperidone. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Risperidone may cause weight gain. Your weight may need to be monitored while you take Risperidone.


• Use Risperidone with caution in the ELDERLY; they may be more sensitive to its effects, especially dizziness upon standing or uncontrolled muscles movements.


• Risperidone should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Contact your doctor if you become pregnant while taking Risperidone or within 12 weeks after the last injection of Risperidone. You will need to discuss the benefits and risks of using Risperidone while you are pregnant. Using Risperidone during the third trimester may result in uncontrolled muscle movements or withdrawal symptoms in the newborn. Discuss any questions or concerns with your doctor. Risperidone is found in breast milk. Do not breast-feed while taking Risperidone and for at least 12 weeks after the last injection of Risperidone.

Possible side effects of Risperidone:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; appetite changes; constipation; cough; dizziness; drowsiness; dry mouth; fatigue; headache; increased saliva production; indigestion; light-headedness; nausea; pain, swelling, or redness at the injection site; restlessness; runny or stuffy nose; stomach pain or upset; trouble sleeping; vomiting; weight gain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thoughts; confusion; drooling; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; inability to control urination; increased sweating; new or worsening mental or mood changes (eg, agitation, aggression, depression, severe anxiety); seizures; severe dizziness; stiff or rigid muscles; suicidal thoughts or attempts; symptoms of high blood sugar (eg, increased thirst, hunger, urination; unusual weakness); tremor; trouble concentrating, speaking, or swallowing; trouble sitting still; trouble walking or standing; uncontrolled muscle movements (eg, arm or leg movements, twitching of the face or tongue, jerking or twisting); unusual bruising; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Risperidone side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fast or irregular heartbeat; severe drowsiness or dizziness; unusual muscle movements.

Proper storage of Risperidone:

Risperidone is usually handled and stored by a health care provider. If you are using Risperidone at home, store Risperidone as directed by your pharmacist or health care provider. Keep Risperidone out of the reach of children and away from pets.

General information:

• If you have any questions about Risperidone, please talk with your doctor, pharmacist, or other health care provider.


• Risperidone is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Risperidone. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Risperidone resources

• Risperidone Side Effects (in more detail)
• Risperidone Use in Pregnancy & Breastfeeding
• Drug Images
• Risperidone Drug Interactions
• Risperidone Support Group
• 102 Reviews for Risperidone - Add your own review/rating

• Risperidone Prescribing Information (FDA)


• Risperidone Professional Patient Advice (Wolters Kluwer)


• Risperidone Monograph (AHFS DI)


• Risperdal Prescribing Information (FDA)


• Risperdal Consumer Overview


• Risperdal Consta Prescribing Information (FDA)


• Risperdal Consta Consumer Overview


• Risperdal Consta Advanced Consumer (Micromedex) - Includes Dosage Information


• risperidone Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Risperidone with other medications

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Valinastin

Valinastin may be available in the countries listed below.

Ingredient matches for Valinastin

Isoconazole

Isoconazole nitrate (a derivative of Isoconazole) is reported as an ingredient of Valinastin in the following countries:

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Spiro-CT may be available in the countries listed below.

Ingredient matches for Spiro-CT

Spironolactone

Spironolactone is reported as an ingredient of Spiro-CT in the following countries:

• Germany

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PMS-Indapamide

PMS-Indapamide may be available in the countries listed below.

Ingredient matches for PMS-Indapamide

Indapamide

Indapamide is reported as an ingredient of PMS-Indapamide in the following countries:

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Dalagis T

Dalagis T may be available in the countries listed below.

Ingredient matches for Dalagis T

Clindamycin

Clindamycin dihydrogen phosphate (a derivative of Clindamycin) is reported as an ingredient of Dalagis T in the following countries:

• Israel

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Metformine Volkspharma

Metformine Volkspharma may be available in the countries listed below.

Ingredient matches for Metformine Volkspharma

Metformin

Metformin hydrochloride (a derivative of Metformin) is reported as an ingredient of Metformine Volkspharma in the following countries:

• Germany

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Cebrotonin

Cebrotonin may be available in the countries listed below.

Ingredient matches for Cebrotonin

Piracetam

Piracetam is reported as an ingredient of Cebrotonin in the following countries:

• Ecuador


• Singapore

International Drug Name Search

Palgic

In the US, Palgic (carbinoxamine systemic) is a member of the drug class antihistamines and is used to treat Allergic Reactions, Allergic Urticaria, Conjunctivitis - Allergic, Dermatographism, Hay Fever and Vasomotor Rhinitis.

US matches:

• Palgic


• Palgic DS Liquid

Ingredient matches for Palgic

Carbinoxamine

Carbinoxamine maleate (a derivative of Carbinoxamine) is reported as an ingredient of Palgic in the following countries:

• United States

International Drug Name Search

Gabapentine Alter

Gabapentine Alter may be available in the countries listed below.

Ingredient matches for Gabapentine Alter

Gabapentin

Gabapentin is reported as an ingredient of Gabapentine Alter in the following countries:

• France

International Drug Name Search

Cefarin

Cefarin may be available in the countries listed below.

Ingredient matches for Cefarin

Cefalexin

Cefalexin monohydrate (a derivative of Cefalexin) is reported as an ingredient of Cefarin in the following countries:

• Indonesia

International Drug Name Search

Thiopental Sandoz

Thiopental Sandoz may be available in the countries listed below.

Ingredient matches for Thiopental Sandoz

Thiopental

Thiopental Sodium is reported as an ingredient of Thiopental Sandoz in the following countries:

• Austria


• Estonia


• Latvia


• Lithuania

International Drug Name Search

Ephedrinum hydrochloridum

Ephedrinum hydrochloridum may be available in the countries listed below.

Ingredient matches for Ephedrinum hydrochloridum

Ephedrine

Ephedrine hydrochloride (a derivative of Ephedrine) is reported as an ingredient of Ephedrinum hydrochloridum in the following countries:

• Poland

International Drug Name Search

Podonin S

Podonin S may be available in the countries listed below.

Ingredient matches for Podonin S

Glutamine

Glutamine is reported as an ingredient of Podonin S in the following countries:

• Japan

Sodium Gualenate

Sodium Gualenate is reported as an ingredient of Podonin S in the following countries:

• Japan

International Drug Name Search

Macrolvet

Macrolvet may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Macrolvet

Aspirin

Acetylsalicylic Acid is reported as an ingredient of Macrolvet in the following countries:

• Portugal

International Drug Name Search

Glaze

Glaze may be available in the countries listed below.

Ingredient matches for Glaze

Gliclazide

Gliclazide is reported as an ingredient of Glaze in the following countries:

• Bahrain


• Oman

International Drug Name Search

Paratropina

Paratropina may be available in the countries listed below.

Ingredient matches for Paratropina

Homatropine

Homatropine Methylbromide is reported as an ingredient of Paratropina in the following countries:

• Argentina

International Drug Name Search

Dihydro CP Syrup

dihydrocodeine bitartrate, chlorpheniramine maleate and pseudoephedrine hydrochloride

Dosage Form: syrup
DiHydro-CP Syrup Antitussive/Antihistamine/Decongestant

Rx Only

CIII


DESCRIPTION

Each teaspoonful (5 mL) for oral administration contains:

Dihydrocodeine Bitartrate.....................................................7.5 mg

(WARNING-May be habit forming)

Chlorpheniramine Maleate.......................................................2 mg

Pseudoephedrine Hydrochloride.............................................15 mg


This product contains the following inactive ingredients:

Citric Acid, Glycerin, Grape Flavor, Propylene Glycol, Purified Water, Sodium Citrate, Sodium Saccharin, Sorbitol.


Dihydrocodeine Bitartrate is an antitussive with the chemical name (Morphine-6-ol,4,5-epoxy-3-methoxy-17methyl-,(5α,6α)-2,3-dihydroxybutanedioate (1:1) (salt).  It has the following structural formula:

Chlorpheniramine Maleate is an antihistamine having the chemical name 2-Pyridinepropanamine,γ-(4-chlorophenyl)-N,N-dimethyl-,(Z)-2-butenedioate (1:1).  It has the following chemical structure:

Pseudoephedrine Hydrochloride is a decongestant having the chemical name, Benzenemethanol, α-[1-(methylamino) ethyl]-,[S-(R*R*)-, hydrochloride. It has the following structural formula:

Dihydro CP Syrup - Clinical Pharmacology

Dihydrocodeine is a semisynthetic narcotic analgesic antitussive related to codeine, with multiple actions qualitatively similar to those of codeine:  the most prominent of these involve the central nervous system and organs with smooth muscle components.


Chlorpheniramine is an alkylamine type antihistamine.  This group of antihistamines is among the most active histamine antagonists and is generally effective in relatively low doses.  The drugs are not so prone to produce drowsiness and are therefore among the most suitable agents for daytime use, but a significant proportion of patients do experience this effect.


Pseudoephedrine Hydrochloride is a sympathomimetic amine, which acts predominately on alpha-receptors and has little action on beta-receptors.  It therefore functions as an oral nasal decongestant with minimal CNS stimulation.

Indications and Usage for Dihydro CP Syrup

This product is indicated for the temporary relief of cough and nasal congestion associated with upper respiratory tract infections and allergies.

Contraindications

This combination product is contraindicated in patients with hypersensitivity to dihydrocodeine, codeine, or any of the active or inactive components listed above, or in any situation where opioids are contraindicated including significant respiratory depression (in unmonitored settings or in the absence of resuscitation equipment), acute or sever bronchial asthma or hypercapnia, and paralytic ileus.  Antihistamines are contraindicated in patients receiving antihypertensive or antidepressant drugs containing monoamine oxidase inhibitors (MAOI) since these agents may prolong and intensify the anticholinergic and CNS depressant effects of antihistamines (see Drug Interactions).


Antihistamines should not be used to treat lower respiratory tract symptoms or be given to newborn infants.


Sympathomimetic agents are contraindicated in patients with severe hypertension, severe coronary artery disease, patients with narrow angle glaucoma, bronchial asthma, urinary retention, peptic ulcer, and during an asthmatic attack.  This product is contraindicated in women who are pregnant.

Warnings

General:  Considerable caution should be exercised in patients with hypertension, diabetes mellitus, ischemic heart disease, hyperthyroidism, increased intracular pressure, and prostatic hypertrophy.  The elderly (60 years and older) are more likely to exhibit adverse reactions.  Antihistamines may cause excitability, especially in children.  At doses higher than the recommended dose, nervousness, dizziness, or sleeplessness may occur.


Usage in Ambulatory Patients:  Dihydrocodeine may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery.


Respiratory Depression:  Respiratory depression is the most dangerous acute reaction produced by opiod agonist preparations, although it is rarely severe with usual doses.  Opioids decrease the respiratory tidal volume, minute ventilation, and sensitivity to carbon dioxide.  Respiratory depression occurs most frequently in elderly or debilitated patients, usually after large initial doses, in non-tolerant patients, or when opioids are given in conjunction with other agents that depress respiration.  This combination product should be used with caution in patients with significant chronic obstructive pulmonary disease or cor pulmonale and in patients with a substantially decreased respiratory reserve, hypoxia, hypercapnia, or respiratory depression.


Hypertensive Effect:  Dihydrocodeine, like all opioid analgesics, may cause hypotension in patients whose ability to maintain blood pressure has been compromised by a depleted blood volume or who received concurrent therapy with drugs such as phenothiazine or other agents which compromise vasomotor tone.  This product may produce orthostatic hypotension in ambulatory patients.  This combination product should be administered with caution to patients with circulatory shock since vasodilation produced by the drug may further reduce cardiac output and blood pressure.


Dependence:  Dihydrocodeine can produce drug dependence of the codeine type and has the potential of being abused.  This product should be prescribed and administered with the appropriate degree of caution (see Drug Abuse and Dependence section).

Precautions

General:  This combination product should be used with caution in elderly or debilitated patients or those with any of the following conditions:  adrenocortical insufficiency (e.g., Addison's disease); asthma; central nervous system depression or coma; chronic obstructive pulmonary disease; decreased respiratory reserve (including emphysema, sever obesity, cor pulmonale, or kyphoscoliosis); delirium tremens; diabetes head injury; hypotension; hypertension; increased intracranial pressure; myxedema or hypothyroidism; prostatic hypertrophy or urethral stricture; and toxic psychosis.  The benefits and risks of opiods in patients taking monoamine oxidase inhibitors and i those with a history of drug abuse should be carefully considered.  This combination product may aggravate convulsions in patients with convulsive disorders, and like all opioids, may induce or aggravate seizures in some clinical settings.

Drug Interactions

Sympathomimetic amines may reduce the antihypertensive effects of methyldopa, mecamylamine, reserpine, and veratrum alkaloids.


Other CNS Depressants:  Patients receiving other opioid analgesics, sedatives or hypnotics, muscle relaxants, general anesthetics, centrally acting anti-emetics, phenothiazines or other tranquilizers, or alcohol concomitantly with this product may exhibit additive depressant effects on the central nervous system.  When such combination therapy is contemplated, the dose of one or both agents should be reduced.  Concomitant use of dihydrocodeine and antihistamines with alcohol and other CNS depressants may have an additive effect.


Monoamine Oxidase Inhibitors:  Dihydrocodeine, like all opioids, interact with monoamine oxidase inhibitors causing central nervous system excitation and hypertension.  MAO inhibitors and beta-adrenergic blockers increase the effects of sympathomimetics.

Information for Patients:

Patients receiving this product should be given the following information:

• This product may inhibit mental or physical abilities required for the performance of potentially hazardous tasks such as driving a care or operating machinery.

• Report any adverse experiences occurring during therapy.

• Do not adjust the dose of this product without consulting the prescribing professional.

• Do not combine this product with alcohol or other central nervous system depressants.

• Women of childbearing potential who become, or are planning to become pregnant should be advised to consult their physician regarding the effects of opioids and other drug use during pregnancy on themselves and their unborn child.

• Patients should be advised that this product is a potential drug of abuse.  They should protect it from theft, and it should never be given to anyone other than the individual for whom it was prescribed.
  

Pregnancy:

Pregnancy Category C:  Animal reproduction studies have not been conducted with this product.  It is also not known whether this combination product can cause fetal harm when administered to pregnant women or can effect reproduction capacity in males and females.  This combination product should be given to a pregnant woman only if clearly needed especially during the first trimester.

Nonteratogenic Effects:

Babies born to mothers who have been taking opioids regularly prior to delivery will be physically dependent.  The withdrawal signs include irritability and excessive crying, tremors, hyperactive reflexes, increased respiratory rate, increased stools, sneezing, yawning, vomiting, and fever.


The intensity of the syndrome does not always correlate with the duration of the maternal opioid use or dose,  There is no consensus on the best method of managing withdrawal.

Chlorpromazine 0.7-1.0 mg/kg q6h, phenobarbital2 mg/kg q6h, and paregoric 2-4 drops/kg q4h, have been used to treat withdrawal symptoms in infants.  The duration of therapy is 4 to 28 days, with dosages decreased as tolerated.

Labor and Delivery:

This product is not recommended for use by women during and immediately before labor and delivery because oral opioids may cause respiratory depression in the newborn.

Nursing Mothers:

Due to the possible passage of the ingredients into breast milk, this product should not be given to nursing mothers.

Pediatric Use:

This product is not recommended for use in children under two years of age.  Children under two years may be more susceptible to respiratory arrest, coma, and death.  Use of antihistamines is not recommended in infants.  This age group may be at higher risk than other age groups because of an increased susceptibility to Anticholinergic effects, such as CNS excitation, and increased tendency toward convulsions.  In older children taking antihistamines, a paradoxical reaction characterized by hyperexcitability may occur.  Very young children may be more susceptible to the effects, especially the vasopressor effects of sympathomimetic amines.

Geriatric Use:

This product should be given with caution to the elderly.


Hepatic Impairment:  This product should be given with caution to patients with hepatic insufficiency.  Since dihydrocodeine is metabolized by the liver the effects of this combination product should be monitored closely in such patients.


Renal Impairment:  This product should be used with caution and at reduced dosage in the presence of impaired renal function.


Pancreatic/biliary Tract Disease:  Opioids may cause spasms of the sphincter of Oddi and should be used with caution in patients with biliary tract disease, including pancreatitis.

Adverse Reactions

The most frequently observed adverse reaction with dihydrocodeine include lightheadedness, dizziness, drowsiness, headache, fatigue, sedation, sweating, nausea, vomiting, constipation, pruritus, and skin reactions.  With the exception of constipation, tolerance develops to most of these effects.  Other reactions that have been observed with dihydrocodeine or opioids include respiratory depression, orthostatic hypotension, cough suppression, confusion, diarrhea, miosis, abdominal pain, dry mouth, indigestion, anorexia, spasm of biliary tract, and urinary retention.  Physical and psychological dependence are possibilities.  Hypersensitivity reactions (include anaphylactoid reactions), hallucinations, vivid dreams, granulomatous interstitial nephritis, sever narcosis and acute renal failure have been reported rarely during dihydrocodeine administration.


Other reactions observed with the ingredients in this product include lassitude, nausea, giddiness, dryness of mouth, blurred vision, cardiac palpitations, flushing, increased irritability or excitement (especially in children).

Drug Abuse and Dependence

This combination product is subject to the provisions of the Controlled Substances Act and has been placed in Schedule III.  Dihydrocodeine can produce drug dependence of the codeine type and therefore has the potential of being abused.  Psychological dependence, physical dependence, and tolerance may develop upon repeat administration of dihydrocodeine, and it should be prescribed and administered with the same degree of caution appropriate to the use of other opioid medications.  Symptoms of dihydrocodeine withdrawal consist of irritability, restlessness, insomnia, diaphoresis, anxiety, and palpitations.

Overdosage

An overdose of this product is a potentially lethal overdose situation, and consultation with a regional Poison Control Center is recommended.  A listing of the Poison Control Center can be found in a standard reference such as the Physician's Desk Reference.


Signs and Symptoms:  Symptoms of an overdose include pinpoint pupils, respiratory depression, extreme somnolence progressing to stupor, loss of consciousness or coma, skeletal muscle flaccidity, cold and clammy skin and other symptoms common with narcotic overdosage.  Convulsions, cardiovascular collapse, and death may occur.  A single case of acute rhabdomyolysis associated with an overdose of dihydrocodeine has been reported.


Recommended Treatment:

Immediate treatment of an overdose of this product includes support of cardiovascular function and measures to reduce further drug absorption.  Vomiting should be induced with syrup of ipecac.  If the patient is alert and has adequate laryngeal reflexes, oral activated charcoal should follow.  The first dose should be accompanied by an appropriate cathartic.  Gastric lavage may be necessary.  Hypotension is usually hypovolemic and should be treated with fluids.


Endotracheal intubation and  artificial respiration may be necessary.  The pure opioid antagonist naloxone or nalmexone is a specific antidote against respiratory depression that results from opioid overdose.  Opioid antagonists should be given in the absence of clinically significant respiratory or circulatory depression secondary to opioid overdose.  They should be administered cautiously to persons who are known, or suspected to be, physically dependent on any opioid agonist including dihydrocodeine.  In such cases, an abrupt or complete reversal of opiod effects may precipitate an acute abstinence syndrome.  The prescribing information for the specific opioid antagonist should be consulted for details of there proper use.

Dihydro CP Syrup Dosage and Administration

Adults and children 12 years of age and over:  1 to 2 teaspoonfuls (5 mL to 10 mL), every

4 to 6 hours as needed;

Children 6 to under 12 years of age:  1/2 to 1 teaspoonful (2.5 mL to 5 mL), every 4 to 6

hours as needed;

Children under 6 years of age: as directed by a physician.

No recommended for children under 2 years of age.

How is Dihydro CP Syrup Supplied

Dihydro-CP Syrup is supplied as a clear, dye free, sugar free, alcohol free syrup with a grape flavor in 16 fl oz (473 mL) bottles, NDC 60258-760-16.


KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.  IN CASE OF ACCIDENTAL OVERDOSE, SEEK PROFESSIONAL ASSISTANCE OR CONTACT A POISON CONTROL CENTER IMMEDIATELY.

STORAGE:

Store at controlled room temperature, 15°-30°C (59°-86°F).


Call your doctor for medical advice about side effects.  You may report side effects to FDA at 1-800-FDA-1088.


Dispense in a tight, light-resistant container as defined in the USP/NF with a child resistant closure.


Tamper evident by foil seal under cap.  Do not use if foil seal is broken or missing.


Rx Only


Manufactured for:

Cypress Pharmaceutical, Inc.

Madison, MS  39110


PIN051616 ISS. 01/10

PRODUCT PACKAGING:

The packaging below represents the labeling currently used:


Principal Display Panel and Side Panel for 473 mL label:


NDC 60258-760-16


DiHydro-CP Syrup


Antitussive/Antihistamine/Decongestant


Each teaspoonful (5 mL) for oral administration contains:

Dihydrocodeine Bitartrate..................................................7.5 mg

(WARNING: May be habit forming)

Chlorpheniramine Maleate....................................................2 mg

Pseudoephedrine HCl.........................................................15 mg


SUGAR FREE/ALCOHOL FREE/DYE FREE


Rx Only


CYPRESS PHARMACEUTICALS, INC.


16 fl oz (473 mL)


USUAL DOSAGE:  Adults and children 12 years of age and over:  1 to 2 teaspoonfuls

(5 mL to 10 mL), every 4 to 6 hours as needed.  Children 6 to under 12 years of age:

1/2 to 1 teaspoonful (2.5 mL to 5 mL), every 4 to 6 hours as needed.

Children under 6 years of age:  as directed by a physician.

Not recommended for children under 2 years of age.


For full prescribing information see attached insert.


KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.  IN CASE

OF ACCIDENTAL OVERDOSE, SEEK PROFESSIONAL ASSISTANCE OR CONTACT A POISON CONTROL CENTER IMMEDIATELY.


Store at controlled room temperature, 15°-30°C(59°-86°F).


Dispense in a tight,light-resistant container as defined in the USP/NF with a child-resistant closure.


Tamper evident by foil seal under cap.  Do not use if foil seal is broken or missing.


This container is not to be dispensed to the consumer.


Manufactured for:  Cypress Pharmaceutical, Inc., Madison, MS  39110


PSL051616  Rev. 01/10

DIHYDRO  CP dihydrocodeine bitartrate, chlorpheniramine maleate, psuedoephedrine hydrochloride  syrup

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 60258-760 Route of Administration ORAL DEA Schedule CIII

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Dihydrocodeine Bitartrate (Dihydrocodeine) Dihydrocodeine Bitartrate 7.5 mg  in 5 mL Chlorpheniramine Maleate (Chlorpheniramine) Chlorpheniramine Maleate 2 mg  in 5 mL Pseudoephedrine Hydrochloride (Pseudoephedrine) Pseudoephedrine Hydrochloride 15 mg  in 5 mL

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color      Score      Shape Size Flavor GRAPE Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 60258-760-16 473 mL In 1 BOTTLE None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
unapproved drug other		02/15/2007

Labeler - Cypress Pharmaceutical, Inc. (790248942)

Revised: 05/2010Cypress Pharmaceutical, Inc.

More Dihydro CP Syrup resources

• Dihydro CP Syrup Side Effects (in more detail)
• Dihydro CP Syrup Dosage
• Dihydro CP Syrup Use in Pregnancy & Breastfeeding
• Dihydro CP Syrup Drug Interactions
• Dihydro CP Syrup Support Group
• 0 Reviews for Dihydro CP - Add your own review/rating

Compare Dihydro CP Syrup with other medications

• Cough and Nasal Congestion

Ataroc

Ataroc may be available in the countries listed below.

Ingredient matches for Ataroc

Procaterol

Procaterol hydrochloride (a derivative of Procaterol) is reported as an ingredient of Ataroc in the following countries:

• Indonesia

International Drug Name Search

Nitogis

Nitogis may be available in the countries listed below.

Ingredient matches for Nitogis

Aspirin

Acetylsalicylic Acid is reported as an ingredient of Nitogis in the following countries:

• Japan

International Drug Name Search

Mucospect

Mucospect may be available in the countries listed below.

Ingredient matches for Mucospect

Carbocisteine

Carbocisteine is reported as an ingredient of Mucospect in the following countries:

• Hong Kong


• South Africa

International Drug Name Search

Glucofor-G

Glucofor-G may be available in the countries listed below.

Ingredient matches for Glucofor-G

Glibenclamide

Glibenclamide is reported as an ingredient of Glucofor-G in the following countries:

• Peru

Metformin

Metformin hydrochloride (a derivative of Metformin) is reported as an ingredient of Glucofor-G in the following countries:

• Peru

International Drug Name Search

Glyburide

In the US, Glyburide (glyburide systemic) is a member of the drug class sulfonylureas and is used to treat Diabetes, Type 2.

US matches:

• Glyburide


• Glyburide Tablets (Micronized)


• Glyburide/Metformin


• Glyburide and metformin


• Glyburide Micronized


• Glyburide/Metformin Hydrochloride

Ingredient matches for Glyburide

Glibenclamide

Glyburide (USAN) is also known as Glibenclamide (Rec.INN)

International Drug Name Search

Glossary

Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Ranitidine FLX

Ranitidine FLX may be available in the countries listed below.

Ingredient matches for Ranitidine FLX

Ranitidine

Ranitidine hydrochloride (a derivative of Ranitidine) is reported as an ingredient of Ranitidine FLX in the following countries:

• Netherlands

International Drug Name Search

Texant

Texant may be available in the countries listed below.

Ingredient matches for Texant

Sodium Hypochlorite

Sodium Hypochlorite is reported as an ingredient of Texant in the following countries:

• Japan

International Drug Name Search

Onic

Onic may be available in the countries listed below.

Ingredient matches for Onic

Omeprazole

Omeprazole is reported as an ingredient of Onic in the following countries:

• Indonesia

International Drug Name Search

Dantrium

Generic Name: dantrolene (Oral route)

DAN-troe-leen

Oral route(Capsule)

Dantrolene has a potential for hepatotoxicity and symptomatic hepatitis (fatal and non-fatal) has been reported at various dose levels of the drug. Risk of hepatic injury appears to be greater in patients taking a higher dosage (800 mg or more per day), in females, in patients over 35 years of age, and in patients taking other medication(s) in addition to dantrolene. Monitor hepatic function including frequent determination of SGOT or SGPT during therapy. Discontinue therapy after 45 days if no observable benefit is derived from therapy .

Commonly used brand name(s)

In the U.S.

• Dantrium

Available Dosage Forms:

• Capsule

Therapeutic Class: Skeletal Muscle Relaxant, Direct Acting

Uses For Dantrium

Dantrolene is used to help relax certain muscles in your body. It relieves the spasms, cramping, and tightness of muscles caused by certain medical problems such as multiple sclerosis (MS), cerebral palsy, stroke, or injury to the spine. Dantrolene does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition. Dantrolene acts directly on the muscles to produce its relaxant effects.

Dantrolene is also used to prevent or treat a medical problem called malignant hyperthermia that may occur in some patients during or following surgery or anesthesia. Malignant hyperthermia consists of a group of symptoms including very high fever, fast and irregular heartbeat, and breathing problems. It is believed that the tendency to develop malignant hyperthermia is inherited.

This medicine is available only with your doctor's prescription.

Before Using Dantrium

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of dantrolene in children below 5 years of age. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of dantrolene in geriatric patients.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Adinazolam


• Alfentanil


• Alprazolam


• Amlodipine


• Amobarbital


• Anileridine


• Aprobarbital


• Bromazepam


• Brotizolam


• Butabarbital


• Butalbital


• Carisoprodol


• Chloral Hydrate


• Chlordiazepoxide


• Chlorzoxazone


• Clobazam


• Clonazepam


• Clorazepate


• Codeine


• Dantrolene


• Diazepam


• Diltiazem


• Estazolam


• Ethchlorvynol


• Felodipine


• Fentanyl


• Flunitrazepam


• Flurazepam


• Halazepam


• Hydrocodone


• Hydromorphone


• Isradipine


• Ketazolam


• Levorphanol


• Lorazepam


• Lormetazepam


• Medazepam


• Meperidine


• Mephenesin


• Mephobarbital


• Meprobamate


• Metaxalone


• Methocarbamol


• Methohexital


• Methotrexate


• Midazolam


• Morphine


• Morphine Sulfate Liposome


• Nicardipine


• Nifedipine


• Nisoldipine


• Nitrazepam


• Nordazepam


• Oxazepam


• Oxycodone


• Oxymorphone


• Pentobarbital


• Phenobarbital


• Prazepam


• Primidone


• Propoxyphene


• Quazepam


• Remifentanil


• Secobarbital


• Sodium Oxybate


• Sufentanil


• Temazepam


• Thiopental


• Triazolam


• Verapamil

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Heart disease or


• Liver disease, history of or


• Lung disease (e.g., emphysema, asthma, bronchitis)—The chance of serious side effects may be increased.

• Liver disease, active (e.g., hepatitis, cirrhosis) or


• Muscle spasms caused by rheumatic disorders—Should not be used in patients with these conditions.

Proper Use of Dantrium

Dantrolene may be taken with or without food or on a full or empty stomach. However, if your doctor tells you to take the medicine a certain way, take it exactly as directed.

Take this medicine only as directed by your doctor. Do not take more of it and do not take it more often than your doctor ordered.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (capsules):
  
  • For prevention or treatment of malignant hyperthermia:
    
    • Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 4 to 8 milligrams (mg) per kilogram (kg) of body weight each day, and is divided in 3 or 4 doses. Your doctor will tell you exactly when and how often to take your medicine.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • To relieve muscle spasms:
    
    • Adults—At first, 25 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 100 mg four times a day.
    
    
    • Children—Dose is based on body weight and must be determined by your doctor. At first, 0.5 milligram (mg) per kilogram (kg) of body weight twice a day. Your doctor may adjust the dose as needed. However, the dose is usually not more than 3 mg per kg four times a day or 100 mg four times a day.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Dantrium

If you will be taking dantrolene for a long time (e.g., several months at a time), your doctor should check your progress at regular visits. Blood tests will be needed to check for unwanted effects.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; other muscle relaxants; or anesthetics, including some dental anesthetics. Therefore, do not drink alcoholic beverages, and check with your doctor before taking any of the medicines listed above, while you are using this medicine.

This medicine may cause drowsiness, dizziness or lightheadedness, vision problems, or muscle weakness in some people. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert, well-coordinated, and able to see well.

This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

Dantrium Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Serious side effects are very rare when dantrolene is taken for a short time, for example, when it is used for a few days before, during, or after surgery or anesthesia to prevent or treat malignant hyperthermia. However, serious side effects may occur, especially when the medicine is taken for a long time.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Bloody or black, tarry stools


• bloody or dark urine


• bluish color changes in skin color


• changes in speech


• chest pain


• confusion


• constipation


• convulsions (seizures)


• decrease in frequency of urination


• decrease in urine volume


• difficult urination


• difficulty in moving


• difficulty in passing urine (dribbling)


• difficulty in swallowing


• fast, pounding, or irregular heartbeat or pulse


• increased frequency of urination


• increased urge to urinate during the night


• joint pain


• light-colored stools


• lightheadedness


• loss of bladder control


• mental depression


• muscle aching or cramping


• muscle pains or stiffness


• muscle spasm or jerking of all extremities


• nausea and vomiting


• pain in lower back


• pain or burning while urinating


• pain, tenderness, or changes in skin color


• painful urination


• severe stomach pain


• shortness of breath


• skin rash, hives, or itching


• slow or troubled breathing


• sudden decrease in amount of urine


• sudden loss of consciousness


• swelling of foot or leg


• swollen joints


• unusual tiredness or weakness


• upper right abdominal pain


• vomiting of blood or material that looks like coffee grounds


• waking to urinate at night


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Diarrhea


• dizziness


• drowsiness


• general feeling of discomfort or illness


• muscle weakness

Less common

• Abdominal or stomach cramps or discomfort


• abnormal hair growth


• acne-like rash


• blurred or double vision or any change in vision


• change in taste


• chills and fever


• disturbed color perception


• excessive tearing


• halos around lights


• headache


• itching skin


• loss of appetite


• night blindness


• overbright appearance of lights


• redness of skin


• seeing double


• skin rash, encrusted, scaly and oozing


• sleeplessness


• slurring of speech or other speech problems


• sudden decrease in amount of urine


• sweating


• trouble in sleeping


• tunnel vision


• unable to sleep


• unusual nervousness


• weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Dantrium side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Dantrium resources

• Dantrium Side Effects (in more detail)
• Dantrium Dosage
• Dantrium Use in Pregnancy & Breastfeeding
• Drug Images
• Dantrium Drug Interactions
• Dantrium Support Group
• 2 Reviews for Dantrium - Add your own review/rating

• Dantrium Prescribing Information (FDA)


• Dantrium MedFacts Consumer Leaflet (Wolters Kluwer)


• Dantrium Concise Consumer Information (Cerner Multum)


• Dantrium Monograph (AHFS DI)


• Dantrolene Prescribing Information (FDA)


• Dantrium Intravenous Prescribing Information (FDA)

Compare Dantrium with other medications

• Malignant Hyperthermia
• Spasticity

Dometic

Dometic may be available in the countries listed below.

Ingredient matches for Dometic

Domperidone

Domperidone is reported as an ingredient of Dometic in the following countries:

• Indonesia


• Sri Lanka

International Drug Name Search

Claritromicina ratiopharm

Claritromicina ratiopharm may be available in the countries listed below.

Ingredient matches for Claritromicina ratiopharm

Clarithromycin

Clarithromycin is reported as an ingredient of Claritromicina ratiopharm in the following countries:

• Italy


• Portugal


• Spain

International Drug Name Search

Sodium Phosphate P 32

Sodium Phosphate P 32 may be available in the countries listed below.

Ingredient matches for Sodium Phosphate P 32

Sodium Phosphate (32P)

Sodium Phosphate P 32 (USAN) is also known as Sodium Phosphate (32P) (Rec.INN)

International Drug Name Search

Glossary

Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Vetitrim

Vetitrim may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Vetitrim

Sulfadimethoxine

Sulfadimethoxine sodium (a derivative of Sulfadimethoxine) is reported as an ingredient of Vetitrim in the following countries:

• Belgium

Trimethoprim

Trimethoprim is reported as an ingredient of Vetitrim in the following countries:

• Belgium

International Drug Name Search

Ganciclovir

In some countries, this medicine may only be approved for veterinary use.

In the US, Ganciclovir (ganciclovir systemic) is a member of the drug class purine nucleosides and is used to treat CMV Retinitis and Cytomegalovirus Infection.

US matches:

• Ganciclovir


• Ganciclovir Capsules


• Ganciclovir Gel


• Ganciclovir Implant


• Ganciclovir ophthalmic


• Ganciclovir oral and injectable


• Ganciclovir Intraocular


• Ganciclovir Oral, Intravenous


• Ganciclovir Sodium

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

J05AB06,S01AD09

CAS registry number (Chemical Abstracts Service)

0082410-32-0

Chemical Formula

C9-H13-N5-O4

Molecular Weight

255

Therapeutic Category

Antiviral agent

Chemical Name

6H-Purin-6-one, 2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-

Foreign Names

• Ganciclovirum (Latin)
• Ganciclovir (German)
• Ganciclovir (French)
• Ganciclovir (Spanish)

Generic Names

• Ganciclovir (OS: BAN, USAN, DCF, JAN)
• BW 759 U (IS)
• DHPG (IS)
• Ganciclovir (PH: USP 32)
• Ganciclovir Sodium (OS: USAN)
• DHPG sodium (IS)
• GCV Sodium (IS)
• Nordeoxyguanosine (IS)

Brand Names

• Ciganclor
  Richmond, Peru



• Citovirax
  Roche, Italy



• Cymeven
  Roche, Bosnia & Herzegowina



• Cymevene
  Recordati, Italy; Roche, United Arab Emirates; Roche, Aruba; Roche, Bahrain; Roche, Brazil; Roche, Chile; Roche, China; Roche, Cuba; Roche, Cyprus; Roche, Estonia; Roche, Egypt; Roche, Spain; Roche, Greece; Roche, Hong Kong; Roche, Ireland; Roche, Israel; Roche, India; Roche, Iran; Roche, Iceland; Roche, Jordan; Roche, Kenya; Roche, Kuwait; Roche, Sri Lanka; Roche, Lithuania; Roche, Luxembourg; Roche, Latvia; Roche, Morocco; Roche, Mauritius; Roche, New Zealand; Roche, Oman; Roche, Philippines; Roche, Pakistan; Roche, Portugal; Roche, Romania; Roche, Serbia; Roche, Russian Federation; Roche, Taiwan; Roche, Ukraine; Roche, Uruguay; Roche, Venezuela; Roche RX, Singapore



• Cytovene
  Roche, United States



• Denosine
  Tanabe Mitsubishi, Japan



• Ganciclovir
  Bestpharma, Chile; Ranbaxy, United States



• Virgan
  Sidus, Argentina; Spectrum Thea, United Kingdom; Thea, Belgium; Thea, Spain; Thea, Poland; Thea, Portugal; Thea, Tunisia; Théa, Germany; Théa, France; Thea-F, Italy



• Virgan (veterinary use)
  Chauvin, United Kingdom



• Vitrasert
  Bausch & Lomb, Australia; Bausch & Lomb, United States; Chiron, Luxembourg



• Zirgan
  Sirion, United States



• Ciganclor
  Richmond, Argentina



• Cymévan
  Roche, France



• Cymeven
  Roche, Brazil; Roche, Germany



• Cymevene
  Roche, Argentina; Roche, Austria; Roche, Australia; Roche, Belgium; Roche, Bulgaria; Roche, Bahrain; Roche, Brazil; Roche, Switzerland; Roche, Colombia; Roche, Czech Republic; Roche, Czech Republic; Roche, Denmark; Roche, Ecuador; Roche, Spain; Roche, Finland; Roche, United Kingdom; Roche, Hong Kong; Roche, Croatia (Hrvatska); Roche, Hungary; Roche, Indonesia; Roche, Israel; Roche, Iceland; Roche, Mexico; Roche, Netherlands; Roche, Norway; Roche, New Zealand; Roche, Peru; Roche, Philippines; Roche, Poland; Roche, Sweden; Roche, Slovakia; Roche, Thailand; Roche, Turkey; Roche, South Africa



• Cytovene
  Roche, Canada; Roche, United States



• Ganciclovir
  Bedford, United States; Richet, Argentina



• Gasmilen
  Ivax, Argentina



• Grinevel
  Filaxis, Argentina

International Drug Name Search

Glossary

BAN	British Approved Name
DCF	Dénomination Commune Française
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Transvercid

Transvercid may be available in the countries listed below.

Ingredient matches for Transvercid

Salicylic Acid

Salicylic Acid is reported as an ingredient of Transvercid in the following countries:

• France

International Drug Name Search

Fénofibrate Fournier Micronisé

Fénofibrate Fournier Micronisé may be available in the countries listed below.

Ingredient matches for Fénofibrate Fournier Micronisé

Fenofibrate

Fenofibrate is reported as an ingredient of Fénofibrate Fournier Micronisé in the following countries:

• France

International Drug Name Search

Rosula Cleanser Emulsion

Pronunciation: sul-fa-SEE-ta-mide/yoor-EE-a
Generic Name: Sulfacetamide/Urea
Brand Name: Examples include Rosula Cleanser and Sulfatol Cleanser

Rosula Cleanser Emulsion is used for:

Treating certain skin conditions (eg, seborrheic dermatitis), dandruff, and certain bacterial infections of the skin. It may also be used for other conditions as determined by your doctor.

Rosula Cleanser Emulsion is a sulfonamide antibiotic. It works by killing bacteria, helping to shed scaly skin, and softening the skin.

Do NOT use Rosula Cleanser Emulsion if:

• you are allergic to any ingredient in Rosula Cleanser Emulsion


• you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide


• you are taking methenamine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Rosula Cleanser Emulsion:

Some medical conditions may interact with Rosula Cleanser Emulsion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of lupus

Some MEDICINES MAY INTERACT with Rosula Cleanser Emulsion. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Silver-containing products (eg, silver sulfadiazine) because they may decrease Rosula Cleanser Emulsion's effectiveness


• Methenamine because it may increase the risk of Rosula Cleanser Emulsion's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Rosula Cleanser Emulsion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Rosula Cleanser Emulsion:

Use Rosula Cleanser Emulsion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Rosula Cleanser Emulsion is for use on the skin only. Wash your hands before and immediately after using Rosula Cleanser Emulsion. Clean the affected area before applying Rosula Cleanser Emulsion. Wet skin and apply plenty of Rosula Cleanser Emulsion. Rub gently into the skin for 10 to 20 seconds to form a full lather, rinse completely, and pat dry.


• To clear up your infection completely, use Rosula Cleanser Emulsion for the full course of treatment. Keep using it even if you feel better in a few days.


• Rosula Cleanser Emulsion works best if it is used at the same time each day.


• Continue to use Rosula Cleanser Emulsion even if you feel well. Do not miss any doses.


• If you miss a dose of Rosula Cleanser Emulsion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Rosula Cleanser Emulsion.

Important safety information:

• It may take several days for Rosula Cleanser Emulsion to work fully.


• Avoid getting Rosula Cleanser Emulsion in your eyes, nose, or mouth.


• Talk with your doctor before you use any other medicines or cleansers on your skin.


• Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.


• Rosula Cleanser Emulsion only works against bacteria; it does not treat viral infections.


• Be sure to use Rosula Cleanser Emulsion for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Long-term or repeated use of Rosula Cleanser Emulsion may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• Rosula Cleanser Emulsion should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Rosula Cleanser Emulsion while you are pregnant. It is not known if Rosula Cleanser Emulsion is found in breast milk after topical use. If you are or will be breast-feeding while you use Rosula Cleanser Emulsion, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Rosula Cleanser Emulsion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Irritation, stinging, or burning of the skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; fever; joint pain; red, swollen, or blistered skin; severe diarrhea; sores in the mouth; stomach cramps/pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Rosula Cleanser Emulsion may be harmful if swallowed. Symptoms of ingestion may include change in the amount of urine; nausea; vomiting.

Proper storage of Rosula Cleanser Emulsion:

Store Rosula Cleanser Emulsion at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Do not freeze. Keep Rosula Cleanser Emulsion out of the reach of children and away from pets.

General information:

• If you have any questions about Rosula Cleanser Emulsion, please talk with your doctor, pharmacist, or other health care provider.


• Rosula Cleanser Emulsion is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Rosula Cleanser Emulsion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Rosula Cleanser resources

• Rosula Cleanser Use in Pregnancy & Breastfeeding
• Rosula Cleanser Support Group
• 0 Reviews for Rosula - Add your own review/rating

Compare Rosula Cleanser with other medications

• Dandruff
• Seborrheic Dermatitis
• Secondary Cutaneous Bacterial Infections

Tolorin

Tolorin may be available in the countries listed below.

Ingredient matches for Tolorin

Tolterodine

Tolterodine tartrate (a derivative of Tolterodine) is reported as an ingredient of Tolorin in the following countries:

• Bangladesh

International Drug Name Search

B & O Supprettes 15-A rectal

Generic Name: belladonna and opium (rectal) (BEL a DON a and OH pee um)

Brand Names: B & O Supprettes 15-A, B & O Supprettes 16-A

What is belladonna and opium?

Belladonna is a natural substance made from a toxic plant. The medicinal form of belladonna has many effects in the body, such as decreasing muscle activity.

Opium is also a natural substance made from the seeds of a plant. The medicinal form of opium is a narcotic pain reliever.

The combination of belladonna and opium is used to treat moderate to severe pain caused by muscle spasms in the tubes that connect the kidneys to the bladder.

Belladonna and opium may also be used for purposes not listed in this medication guide.

What is the most important information I should know about belladonna and opium?

Do not take belladonna and opium rectal by mouth. It is for use only in your rectum. You should not use belladonna and opium if you have glaucoma, a muscle disorder, severe breathing problems, diarrhea caused by infection, severe liver or kidney disease, seizures, severe bleeding, a history of head injury, if you are debilitated, or if you have recently used drugs or alcohol. There are many other drugs that should not be used together with belladonna and opium rectal. Tell your doctor about all other medicines you use.

Before using belladonna and opium, tell your doctor about all of your medical conditions.

Opium may be habit-forming and should be used only by the person it was prescribed for. Never share this medication with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

What should I discuss with my health care provider before using B & O Supprettes 15-A (belladonna and opium (rectal))?

Do not use belladonna and opium if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) within the past 14 days.

Do not use belladonna and opium if you are also using linezolid (Zyvox), pramlintide (Symlin), procarbazine (Matulane), naltrexone (ReVia), or potassium supplement tablets or capsules.

You should not use this medication if you are allergic to belladonna or opium, or if you have:

• 
  

  glaucoma;

  
  


• 
  

  urination problems or an enlarged prostate;

  
  


• 
  

  severe liver or kidney disease;

  
  


• 
  

  a blockage in your stomach or intestines;

  
  


• 
  

  a history of head injury or brain tumor;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  diarrhea caused by infection;

  
  


• 
  

  severe bleeding;

  
  


• 
  

  a muscle disorder such as myasthenia gravis;

  
  


• 
  

  asthma or severe breathing disorder;

  
  


• 
  

  if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications; or

  
  


• 
  

  if you are bed-ridden or otherwise debilitated.

  
  

To make sure you can safely use belladonna and opium, tell your doctor if you have any of these other conditions:

• 
  

  liver or kidney disease;

  
  


• 
  

  heart disease, high or low blood pressure;

  
  


• 
  

  a stomach or intestinal disorder;

  
  


• 
  

  chronic obstructive pulmonary disease (COPD) or other breathing problems;

  
  


• 
  

  depression or mental illness;

  
  


• 
  

  curvature of the spine;

  
  


• 
  

  gallbladder disease;

  
  


• 
  

  Addison's disease or other adrenal gland disorders;

  
  


• 
  

  underactive thyroid;

  
  


• 
  

  drug or alcohol addiction; or

  
  


• 
  

  an allergy to atropine or any narcotic pain medicine such as hydrocodone (Lortab, Vicodin), morphine (Kadian, MS Contin, Oramorph, and others), oxycodone (OxyContin), and others.

  
  

FDA pregnancy category C. It is not known whether belladonna and opium will harm an unborn baby. Opium may cause addiction or withdrawal symptoms in a newborn if the mother uses the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether belladonna and opium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Opium may be habit-forming and should be used only by the person it was prescribed for. Never share this medication with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

How should I use B & O Supprettes 15-A (belladonna and opium (rectal))?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Do not take a belladonna and opium rectal suppository by mouth. It is for use only in your rectum. Wash your hands before and after inserting the rectal suppository.

Try to empty your bowel and bladder just before using the belladonna and opium suppository.

Remove the outer wrapper from the suppository before inserting it. Avoid handling the suppository too long or it will melt in your hands.

Lie on your back with your knees up toward your chest. Gently insert the suppository into your rectum about 1 inch.

For best results, stay lying down after inserting the suppository and hold it in your rectum for a few minutes. The suppository will melt quickly once inserted and you should feel little or no discomfort while holding it in. Avoid using the bathroom for at least an hour after using the suppository.

Drink plenty of water to prevent constipation while using belladonna and opium.

Belladonna and opium rectal is most often used 1 or 2 times per day. Do not use the suppositories more than 4 times per day. Follow your doctor's instructions. Call your doctor if your symptoms do not improve, or if they get worse while using this medication.

Do not stop using the medication suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when you stop using belladonna and opium rectal. Store at room temperature away from moisture, heat, and light. Do not refrigerate or freeze the suppositories. Ask your pharmacist how to properly dispose of any unused suppositories that are no longer needed. Keep track of the amount of medicine used from each new supply of this medication. Opium is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?

Since belladonna and opium is used on an as needed basis, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include feeling restless or excited, confusion or unusual behavior, muscle weakness, weak or shallow breathing, fainting, or coma.

What should I avoid while using belladonna and opium?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid becoming overheated or dehydrated during exercise and in hot weather. This medication can decrease sweating and you may be more prone to heat stroke.

Drinking alcohol can increase certain side effects of belladonna and opium.

Belladonna and opium side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  painful or difficult urination;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  fast heart rate;

  
  


• 
  

  weak, shallow breathing;

  
  


• 
  

  extreme weakness, feeling like you might pass out;

  
  


• 
  

  headache, confusion; or

  
  


• 
  

  severe constipation and stomach pain.

  
  

Less serious side effects may include:

• 
  

  drowsiness, dizziness;

  
  


• 
  

  blurred vision;

  
  


• 
  

  nausea, vomiting, constipation;

  
  


• 
  

  dry mouth, dry eyes;

  
  


• 
  

  decreased sense of taste; or

  
  


• 
  

  impotence, loss of interest in sex, or trouble having an orgasm.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect belladonna and opium?

Many drugs can interact with belladonna and opium. Below is just a partial list. Tell your doctor if you are using:

• 
  

  a blood thinner such as warfarin (Coumadin);

  
  


• 
  

  cimetidine (Tagamet);

  
  


• 
  

  rifampin (Rifadin, Rifater, Rifamate);

  
  


• 
  

  cold or allergy medicines;

  
  


• 
  

  an antidepressant such as amitriptyline (Elavil, Etrafon), nortriptyline (Pamelor), trazodone (Desyrel), and others;

  
  


• 
  

  medicine to treat a mental illness, such as clozapine (Clozaril, FazaClo), chlorpromazine (Thorazine), and others;

  
  


• 
  

  diazepam (Valium) or similar medicines such as alprazolam (Xanax), clorazepate (Tranxene), lorazepam (Ativan), midazolam (Versed), temazepam (Restoril), triazolam (Halcion), and others;

  
  


• 
  

  a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), and others; or

  
  


• 
  

  narcotic medicine such as fentanyl (Actiq, Duragesic), hydrocodone (Lortab, Vicodin, Vicoprofen), methadone (Dolophine, Methadose), morphine (Avinza, Kadian, MS Contin, Oramorph), oxycodone (OxyContin, Percocet, Combunox), and others.

  
  

This list is not complete and other drugs may interact with belladonna and opium. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More B & O Supprettes 15-A resources

• B & O Supprettes 15-A Side Effects (in more detail)
• B & O Supprettes 15-A Use in Pregnancy & Breastfeeding
• B & O Supprettes 15-A Drug Interactions
• B & O Supprettes 15-A Support Group
• 2 Reviews for B & O Supprettes5-A - Add your own review/rating

Compare B & O Supprettes 15-A with other medications

• Overactive Bladder

Where can I get more information?

• Your pharmacist can provide more information about belladonna and opium rectal.

See also: B & O Supprettes5-A side effects (in more detail)